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Cystatin C is a disease‐associated protein subject to multiple regulation
Author(s) -
Xu Yuekang,
Ding Ying,
Li Xinchen,
Wu Xiaobing
Publication year - 2015
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2014.121
Subject(s) - proteases , cystatin c , protease , cystatin , biology , function (biology) , protease inhibitor (pharmacology) , renal function , cysteine protease , microbiology and biotechnology , regulator , enzyme , biochemistry , immunology , gene , human immunodeficiency virus (hiv) , antiretroviral therapy , viral load
A protease inhibitor, cystatin C (Cst C), is a secreted cysteine protease inhibitor abundantly expressed in body fluids. Clinically, it is mostly used to measure glomerular filtration rate as a marker for kidney function due to its relatively small molecular weight and easy detection. However, recent findings suggest that Cst C is regulated at both transcriptional and post‐translational levels, and Cst C production from haematopoietic cell lineages contributes significantly to the systematic pools of Cst C. Furthermore, Cst C is directly linked to many pathologic processes through various mechanisms. Thus fluctuation of Cst C levels might have serious clinical implications rather than a mere reflection of kidney functions. Here, we summarize the pathophysiological roles of Cst C dependent and independent on its inhibition of proteases, outline its change of expression by various stimuli, and elucidate the regulatory mechanisms to control this disease‐related protease inhibitor. Finally, we discuss the clinical implications of these findings for translational gains.