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Natural cytotoxicity receptors and their ligands
Author(s) -
Kruse Philip H,
Matta Jessica,
Ugolini Sophie,
Vivier Eric
Publication year - 2014
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2013.98
Subject(s) - cytotoxicity , receptor , biology , microbiology and biotechnology , innate lymphoid cell , pathogen , cell , broad spectrum , innate immune system , immunology , chemistry , in vitro , biochemistry , combinatorial chemistry
Natural killer (NK) cells are innate lymphoid cells (ILCs) that participate to the clearance of pathogen‐infected cells and tumour cells. NK cells and subsets of ILCs express the natural cytotoxicity receptors (NCRs) NKp46, NKp44 and NKp30 at their surface. NCRs have been shown to recognize a broad spectrum of ligands ranging from viral‐, parasite‐ and bacterial‐derived ligands to cellular ligands; however, the full identification of NCR ligands remains to be performed and will undoubtedly contribute to a better understanding of NK cell and ILC biology.