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Priming of T follicular helper cells by dendritic cells
Author(s) -
BallesterosTato André,
Randall Troy D
Publication year - 2014
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2013.62
Subject(s) - priming (agriculture) , follicular dendritic cells , follicular phase , immunology , biology , microbiology and biotechnology , antibody , cellular differentiation , germinal center , t cell , antigen presenting cell , b cell , immune system , genetics , gene , botany , germination
T follicular helper cells (Tfh) are required to generate long‐lived antibody responses, which confer long‐term protection to pathogens following vaccination or infection. Despite significant advances in the field, however, little is known about the early steps that drive Tfh cell differentiation. In this review, we will discuss the mechanisms by which dendritic cells promote the initial commitment of activated CD4 + T cells to the Tfh cell differentiation pathway.