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Intestinal DC in migrational imprinting of immune cells
Author(s) -
Stock Angus,
Napolitani Giorgio,
Cerundolo Vincenzo
Publication year - 2013
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2012.73
Subject(s) - immune system , homing (biology) , biology , immunology , lymphocyte homing receptor , antigen , dendritic cell , retinoic acid , cd8 , antigen presenting cell , microbiology and biotechnology , t cell , cell , cell culture , cell adhesion , ecology , genetics
Dendritic cells (DCs) have a pivotal role in instructing antigen‐specific immune responses, processing and presenting antigens to CD4 + and CD8 + T cells and producing factors capable to modulate the quality of T‐cell responses. In this review, we will provide an historic overview on the identification of the mechanisms controlling lymphocyte migration into the largest immune organ of the body: the gut, and we will describe how in recent years an unexpected role for DCs has emerged as the architects in programming gut‐homing immune cells. Specifically, we will review how intestinal DCs utilize the dietary vitamin A metabolite retinoic acid (RA) to program gut‐homing lymphocytes and how intestinal DCs acquire the unique capacity to become RA producers.