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A look at the interface between mesenchymal stromal cells and the immune system
Author(s) -
Ceredig Rhodri
Publication year - 2013
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2012.68
Subject(s) - mesenchymal stem cell , immune system , stromal cell , bone marrow , haematopoiesis , computer science , interface (matter) , biology , immunology , cancer research , microbiology and biotechnology , stem cell , maximum bubble pressure method , parallel computing , bubble
The January 2013 issue contains a Special Feature Focussing on the interface between mesenchymal stromal cells and the immune system . Mesenchymal stromal cells (MSCs) are known to play a fundamental role in supporting hematopoiesis and are multipotent. This knowledge has led to significant interest to determine the potential of using MSCs both to enhance hematopoietic recovery following bone marrow transplantation and also for regenerative medical purposes. Further studies showed that MSCs also had immunosuppressive activity on both the adaptive and natural immune system, thereby endorsing them as the perfect cell source for tissue repair. The Special Feature contains review articles covering topics that largely focus on the interactions of MSCs with cells of the immune system. Further background information on this important topic is available through the accompanying web focus which links to related articles from across Nature Publishing Group.