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Chromatin organizer SATB1 is an important determinant of T‐cell differentiation
Author(s) -
Burute Mithila,
Gottimukkala Kamal,
Galande Sanjeev
Publication year - 2012
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2012.28
Subject(s) - chromatin , wnt signaling pathway , biology , transcription factor , cellular differentiation , microbiology and biotechnology , regulator , cell fate determination , signal transduction , genetics , gene
T‐cell development and differentiation is coordinated by a multitude of signaling molecules and transcription factors that impart distinct functional properties to progenitors. In this review, we focus on the role of the T lineage‐enriched chromatin organizer and regulator SATB1 in T‐cell differentiation. SATB1 mediates Wnt signaling by recruiting β‐catenin to its genomic targets and coordinates T helper type 2 (T H 2) differentiation by positively regulating GATA‐3. In contrast, maintenance of regulatory T cell (Treg) functions are dependent on inhibition of SATB1‐mediated modulation of global chromatin organization. We discuss how regulation of the activity of SATB1 has a critical role in driving these two important differentiation pathways in T cells.

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