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Overview. Type I interferons as primers, activators and inhibitors of innate and adaptive immune responses
Author(s) -
Hertzog Paul J
Publication year - 2012
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2012.15
Subject(s) - innate immune system , immune system , biology , acquired immune system , immunology , effector , sophistication , interferon , microbiology and biotechnology , sociology , social science
The innate immune response recognises pathogens and sterile danger signals to generate effector cytokines, such as type I interferons (IFNs), with a high degree of sophistication. The May/June 2012 issue provides a series of reviews of the role of type I IFNs in regulating immune responses. Topics to be covered include the reason for the induction of IFNs, type I IFNs interactions with and regulation of target cells (e.g. T cells, B cells and Th10 cells) in the immune system, and the roles and mechanisms of IFNs in specific organs or diseases. The accompanying web focus presents links to related articles from across Nature Publishing Group to provide more background information about these proteins.