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HDACi: molecular mechanisms and therapeutic implications in the innate immune system
Author(s) -
Suliman Bandar Ali,
Xu Dakang,
Williams Bryan RG
Publication year - 2012
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2011.92
Subject(s) - innate immune system , histone deacetylase , biology , immunology , immune system , nod , cancer research , immunity , inflammation , histone , in vivo , gene , biochemistry , microbiology and biotechnology
Histone deacetylase inhibitors (HDACi) are an emerging class of novel anti‐cancer drugs that cause growth arrest, differentiation and apoptosis of tumor cells. In addition, many advances have been made in understanding the immunoregulation of Toll‐like receptors, NOD‐like receptors and interferons that have recently generated new momentum for the study of HDACi in immunity as a whole, and in the regulation of these innate signaling pathways specifically. HDACi have shown promise as new anti‐inflammatory and immunosuppressant agents. They have also demonstrated great potency and relative selectivity in various human/animal models of inflammatory diseases. This review focuses on recent progress and the current state of HDACi knowledge, as well as the molecular mechanisms and therapeutic potential of HDACi for the treatment of inflammatory diseases and cancers.

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