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MicroRNAs regulatory networks in myeloid lineage development and differentiation: regulators of the regulators
Author(s) -
El Gazzar Mohamed,
McCall Charles E
Publication year - 2012
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2011.74
Subject(s) - reprogramming , biology , microrna , microbiology and biotechnology , transcription factor , myeloid , function (biology) , regulation of gene expression , cellular differentiation , immune system , phenotype , cell fate determination , dendritic cell , gene regulatory network , gene , gene expression , genetics , immunology
MicroRNAs (miRNAs) are abundant small molecules of ∼22 nucleotides that reprogram gene expression by targeting mRNA degradation and translation disruption. An emerging concept implicates miRNA coupling with transcription factors in myeloid‐based development of dendritic cells, monocytes and granulocytes, as well as function as mature cells and contributors to host defense and inflammation. Here, we review this new and important interactive circuitry and how it contributes to reprogramming cell phenotypic responses associated with mature immune competency.