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ONZIN deficiency attenuates contact hypersensitivity responses in mice
Author(s) -
Ledford Julie G,
Kovarova Martina,
Jania Leigh A,
Nguyen MyTrang,
Koller Beverly H
Publication year - 2012
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2011.107
Subject(s) - hapten , effector , immune system , immunology , antigen , biology , delayed hypersensitivity
ONZIN is abundantly expressed in immune cells of both the myeloid and lymphoid lineage. Expression by lymphoid cells has been reported to further increase after cutaneous exposure of mice to antigens and haptens capable of inducing contact hypersensitivity (CHS), suggesting that ONZIN has a critical role in this response. Here, we report that indeed ONZIN‐deficient mice develop attenuated CHS to a number of different haptens. Dampened CHS responses correlated with a significant reduction in pro‐inflammatory IL‐6 at the challenge site in ONZIN‐deficient animals, compared with wild‐type controls. Together the study of these animals indicates that loss of ONZIN impacts the effector phase of the CHS response through the regulation of pro‐inflammatory factors.