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Atopic dermatitis: the role of Langerhans cells in disease pathogenesis
Author(s) -
Dubrac Sandrine,
Schmuth Matthias,
Ebner Susanne
Publication year - 2010
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2010.33
Subject(s) - atopic dermatitis , pathogenesis , disease , immunology , inflammation , skin barrier , medicine , dermatology , pathology
The manifestation of atopic dermatitis (AD) results from a complex interaction of environmental factors, skin barrier defects and immunological phenomena. The initial events in AD remain unclear while much progress has been made in identifying the mechanisms leading to the manifestation and maintenance of allergic inflammation. AD pathogenesis can be approached from many different points of view. In this review, we describe findings in mouse models and in humans separately. We focus on recent findings that underscore the importance of Langerhans cells in initial mechanisms of skin inflammation in AD.