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Dendritic cells and humoral immunity in humans
Author(s) -
Ueno Hideki,
Schmitt Nathalie,
Palucka A Karolina,
Banchereau Jacques
Publication year - 2010
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2010.28
Subject(s) - humoral immunity , immunology , immune system , biology , acquired immune system , immunity , cytotoxic t cell , follicular dendritic cells , dendritic cell , cellular immunity , innate immune system , microbiology and biotechnology , t cell , antigen presenting cell , in vitro , biochemistry
Dendritic cells (DCs) orchestrate the innate and adaptive immune systems to induce tolerance and immunity. DC plasticity and subsets are prominent determinants in the regulation of immune responses. Our recent studies suggest that humoral and cellular immunity is regulated by different myeloid DC subsets with distinct intrinsic properties in humans. Although antibody response is preferentially mediated by CD14 + dermal DCs, cytotoxic T‐cell response is preferentially mediated by Langerhans cells (LCs). Thus, mechanisms whereby DCs induce humoral and cellular immunity seem to be fundamentally distinct. In this review, we will focus on the role of DCs in the development of humoral immunity. We will also discuss the mechanisms whereby DCs induce CD4 + T cells associated with aiding B‐cell response, including T follicular helper (Tfh) cells, and why human LCs lack this ability.