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Polycomb group protein Bmi1 negatively regulates IL‐10 expression in activated macrophages
Author(s) -
Sienerth Arnold R,
Scheuermann Christian,
Galmiche Antoine,
Rapp Ulf R,
Becker Matthias
Publication year - 2011
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2010.160
Subject(s) - bmi1 , repressor , lipopolysaccharide , cytokine , chromatin , polycomb group proteins , phosphorylation , interleukin 6 , interleukin 8 , microbiology and biotechnology , chemistry , cancer research , biology , immunology , gene expression , stem cell , biochemistry , gene
Macrophages exert a wide variety of functions, which necessitate a high level of plasticity on the chromatin level. In the work presented here, we analyzed the role of the polycomb group protein Bmi1 during the acute response of bone marrow derived macrophages (BMDM) to lipopolysaccharide (LPS). Unexpectedly, we observed that Bmi1 was rapidly induced at the protein level and transiently phosphorylated upon LPS treatment. The induction of Bmi1 was dependent on MAP‐kinase signaling. LPS treatment of BMDM in the absence of Bmi1 resulted in a pronounced increase in expression of the anti‐inflammatory cytokine interleukin‐10 (IL‐10). Our results identify Bmi1 as a repressor of IL‐10 expression during macrophage activation.