Premium
Human FoxP3 + CD4 + regulatory T cells: their knowns and unknowns
Author(s) -
Miyara Makoto,
Sakaguchi Shimon
Publication year - 2011
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2010.137
Subject(s) - foxp3 , transcription factor , human disease , immune system , immunology , biology , homeostasis , immune tolerance , microbiology and biotechnology , computational biology , genetics , gene
Human regulatory T cells (Tregs) expressing the transcription factor FoxP3 play indispensable roles for the maintenance of immunological self‐tolerance and immune homeostasis. In this review, we discuss immunological characteristics of human FoxP3 + Tregs and to what extent they are similar to or different from the murine counterparts. We also discuss important issues that remain to be addressed in the field to better understand the pathophysiology of autoimmune disease and to build solid basis for immunotherapies targeting FoxP3 + Tregs.