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Shaping the T‐cell repertoire in the periphery
Author(s) -
Allen Stacey,
Turner Stephen J,
Bourges Dorothée,
Gleeson Paul A,
Driel Ian R
Publication year - 2011
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2010.133
Subject(s) - biology , immune system , negative selection , repertoire , immunology , microbiology and biotechnology , organism , t cell , cell , genetics , gene , physics , genome , acoustics
Selection of T cells does not end with events in the thymus, but continues in extrathymic tissues and for the life of the organism. In this review, we examine how self‐reactive T cells are rendered harmless and the processes that select for T cells that are most efficient at combating pathogens. The implications of peripheral T‐cell selection for the immune response as animals age are discussed as is the critical role of dendritic cells in directing T‐cell differentiation.