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Molecular and genetic parameters defining T‐cell clonal selection
Author(s) -
Labrecque Nathalie,
Baldwin Troy,
Lesage Sylvie
Publication year - 2011
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2010.119
Subject(s) - biology , clonal deletion , clonal selection , selection (genetic algorithm) , repertoire , negative selection , somatic evolution in cancer , positive selection , genetics , genome , computational biology , evolutionary biology , t cell , immunology , gene , t cell receptor , immune system , physics , artificial intelligence , computer science , acoustics
Clonal selection of T cells occurs in the thymus and is responsible for generating a useful and functional repertoire of T cells. Aberrations in clonal selection result in altered T‐cell homeostasis in the secondary lymphoid organs ranging from an absence of T cells to an overabundance of autoreactive T cells. The advent of new technologies facilitating the manipulation of the mouse genome has helped refine our understanding of the molecular and genetic pathways involved in clonal selection and has also revealed a high degree of complexity. Herein, we attempt to review recent advances in thymic selection processes, achieved mostly through genetic manipulations.