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Antigen‐driven T‐cell repertoire selection during adaptive immune responses
Author(s) -
Baumgartner Christina K,
Malherbe Laurent P
Publication year - 2011
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2010.117
Subject(s) - repertoire , biology , immune system , acquired immune system , antigen , cd8 , immunology , t cell receptor , t cell , cytotoxic t cell , microbiology and biotechnology , genetics , in vitro , physics , acoustics
Protective immunity against a variety of infections depends on the amplification and differentiation of rare naïve antigen‐specific CD4 and CD8 T cells. Recent evidence indicates that the clonotypic composition of the responding T‐cell compartment has a critical role in the immune defense against pathogens. The present review compares and contrasts how naive CD4 and CD8 T cells recognize their cognate antigen, and discusses the factors that regulate the genesis and maintenance of the CD4 and CD8 T‐cell receptor repertoire diversity.