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SOCS1 negatively regulates the production of Foxp3 + CD4 + T cells in the thymus
Author(s) -
Zhan Yifan,
Davey Gayle M,
Graham Kate L,
Kiu Hiu,
Dudek Nadine L,
Kay Thomas WH,
Lew Andrew M
Publication year - 2009
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2009.23
Subject(s) - il 2 receptor , suppressor of cytokine signaling 1 , foxp3 , cd8 , t cell , cytotoxic t cell , biology , microbiology and biotechnology , chemistry , immunology , immune system , in vitro , biochemistry , gene , suppressor
SOCS1 profoundly influences the development and peripheral homeostasis of CD8 + T cells but has less impact on CD4 + T cells. Despite the moderate influence of SOCS1 in the development of the total CD4 T‐cell lineage, we show here that SOCS1 deficiency resulted in a 10‐fold increase in Foxp3 + CD4 + T cells in the thymus. Increased numbers of Foxp3 + thymocytes occurred in mice with T‐cell‐specific ablation of SOCS1, suggesting that the effect is T‐cell intrinsic. This increase in Foxp3 + CD4 + cells in SOCS1‐deficient mice also occurred in the absence of IFN‐γ or/and IL‐7 signaling. Increase in CD25 + CD4 + T cells in the absence of SOCS1 could be partly due to enhanced survival by CD25 + CD4 + cells, to a lesser degree CD25 − CD4 + T cells, from SOCS1‐deficient mice with or without T‐cell growth factors.