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On the opposing views of the self–nonself discrimination by the immune system
Author(s) -
Cohn Melvin
Publication year - 2009
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2008.96
Subject(s) - miller , popularity , self tolerance , associative property , psychology , cognitive science , epistemology , immunology , biology , immune system , social psychology , philosophy , ecology , autoimmunity , mathematics , pure mathematics
Today's generally accepted view of the self–nonself discrimination was voiced by Miller 1 in 2004 in a thought‐provoking essay. In spite of its popularity, this position has its limitations, which are analyzed here with a view toward establishing an interactive discussion that hopefully will culminate in agreed upon decisive experiments. The inadequacies of Miller's view of the self–nonself discrimination and their resolution under the associative recognition of antigen model are analyzed.