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The cell biology of cross‐presentation and the role of dendritic cell subsets
Author(s) -
Lin MingLee,
Zhan Yifan,
Villadangos Jose A,
Lew Andrew M
Publication year - 2008
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2008.3
Subject(s) - cross presentation , antigen presentation , microbiology and biotechnology , biology , antigen , cd8 , dendritic cell , antigen presenting cell , antigen processing , t cell , immunology , mhc class i , immune system
The cell biology of cross‐presentation is reviewed regarding exogenous antigen uptake, antigen degradation and entry into the major histocompatibility complex class I pathway. Whereas cross‐presentation is not associated with enhanced phagocytic ability, certain receptors may favour uptake for cross‐presentation for example mannose receptor for soluble glycoproteins. Perhaps, the defining property of the cross‐presenting cell is some specialization in host machinery for handling and transport of antigen across organelles. Both cytosolic and vacuolar pathways are discussed. Which dendritic cell (DC) subset is the cross‐presenting cell is explored. Cross‐presentation is found within the CD8 + subset resident in lymphoid organs. The role of other DC subsets (especially the migratory CD8 − DC) and the route of antigen delivery are also discussed. Further consideration is given to antigen transfer between DC subsets and differential presentation to naive vs memory T cells.