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The suppression of hypersensitivity by ocular‐induced CD8 + T cells requires compatibility in the Qa‐1 haplotype
Author(s) -
Cone Robert E,
Chattopadhyay Subhasis,
Sharafieh Roshanak,
Lemire Yen,
O'Rourke James
Publication year - 2009
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2008.102
Subject(s) - antigen , cd8 , bystander effect , cytotoxic t cell , immunology , chemistry , microbiology and biotechnology , biology , in vitro , biochemistry
The injection of antigen into the anterior chamber (AC, intracameral injection) of a murine eye induces the generation of splenic CD8 + regulatory T cells (AC‐SPL cells) that effect the antigen‐specific suppression of a delayed‐type hypersensitivity (DTH) reaction. Here we show (i) for the first time that the local antigen‐specific suppression of DTH‐induced swelling in immunized mice either by an intracameral injection of antigen or by the direct injection of CD8 + AC‐SPL cells into an antigen‐challenged site is associated with an absence of infiltrated mononuclear cells, (ii) that the local antigen‐specific suppression of the DTH reaction by CD8 + AC‐SPL cells requires compatibility between the Qa‐1 but not H2 antigen haplotype of the immunized recipient and the injected AC‐SPL regulatory T cells, (iii) that the suppression of the DTH reaction by CD8 + AC‐SPL cells requires the expression of Qa‐1 but not H2 antigens and is not due to bystander suppression.