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DNA vaccines against tuberculosis
Author(s) -
Lowrie Douglas B,
Silva Celio L,
Tascon Ricardo E
Publication year - 1997
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1997.93
Subject(s) - dna vaccination , adoptive cell transfer , virology , antigen , biology , immunology , tuberculosis , immunity , vaccination , tuberculosis vaccines , dna , mycobacterium tuberculosis , immune system , medicine , immunization , t cell , genetics , pathology
This edited transcript of a presentation at the‘Vaccines Beyond 2000’conference series of investigations by the authors throwing light on the mechanisms of protective immunity against tuberculosis in mice and raising hope for a new kind of vaccine to replace bacille Calmette‐Guérin (BCG), DNA encoding only one or a few protein antigens was found capable of conferring persistent protection equal to the effect of BCG. The essential features seem to be an endogenous origin of the antigen within transfected mouse cells which favours the development of CD8 + /CD44 hi /IFN‐γ‐producing T cells with antigen‐specific cytotoxicity. Such cells were the most efficient in adoptive transfer of protection from infected or DNA‐vaccinated mice to naive mice.