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Production of B cell differentiation factors by mouse parenchymal liver cells
Author(s) -
Takahashi Megumi,
Watari Eiji,
Mabuchi Ayako,
Yokomuro Kozo
Publication year - 1997
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1997.89
Subject(s) - transforming growth factor beta , parenchyma , biology , transforming growth factor , antibody , cell , microbiology and biotechnology , immunology , biochemistry , botany
Previously we reported that most antibody secreting cells secreted IgA in the liver. Here we assessed the possibility that parenchymal liver cells (PLC) produced factors, transforming growth factor (TGF)‐p and IL‐5, which participate in the differentiation of B cells to IgA‐secreting cells. We showed that TGF‐p activity was present in the culture supernatant of PLC. and IL‐5 activity was in the lysate of PLC. Moreover, it was confirmed that IL‐5 protein produced by PLC was mainly localized in the cell membrane by histochemical staining. The findings that both TGF‐P and IL‐5 were produced by PLC should provide useful information concerning the fact that IgA‐secreting cells were dominant in the liver.