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Modulation of experimental allergic encephalomyelitis in mice by immunization with a peptide specific for the γδ T cell receptor
Author(s) -
Olive Colleen
Publication year - 1997
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1997.14
Subject(s) - encephalomyelitis , immunization , receptor , peptide , immunology , modulation (music) , neuroscience , microbiology and biotechnology , biology , medicine , immune system , physics , biochemistry , multiple sclerosis , acoustics
This study investigated the role of γδ T cells in experimental allergic encephalomyelitis (EAE), a chronic inflammatory disease of the central nervous system (CNS) that resembles multiple sclerosis. The strategy was to assess the effect on EAE of TCR peptide immunization directed against Vγ6 T cells, shown recently to predominate in the CNS of mice during the early stages of EAE. The data show that TCR peptide immunization specific for Vγ6 chains does not induce protection against EAE, since the incidence of EAE in TCR treated animals was similar to control mice, and therefore does not affect disease susceptibility per se , but rather alters the development of the disease, Specifically, there was a delay in the onset of EAE and a reduction in disease severity in TCR treated animals, although the effects were not highly significant. These findings suggest a role for γδ T cells in the development of EAE; however, further studies are necessary to confirm the specificity of TCR peptide immunization.