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Mechanisms of interference with the MHC class I‐restricted pathway of antigen presentation by herpesviruses
Author(s) -
HILL ANN B
Publication year - 1996
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1996.85
Subject(s) - antigen presentation , biology , mhc class i , herpes simplex virus , virology , cytotoxic t cell , antigen , antigen processing , major histocompatibility complex , immunology , viral interference , virus , immune system , genetics , viral replication , t cell , in vitro
Summary. Herpesviruses are an ancient, ubiquitous family of DNA viruses, most of which share a lifestyle of latently or persistently infecting a young host, and spreading to infect a new host a generation later. Most herpesviruses interfere with antigen presentation via the MHC class I‐restricted pathway of antigen presentation, suggesting that impairment of the cytotoxic T lymphocyte response is necessary for the maintenance of this lifestyle. The diverse molecular mechanisms that have so far been discovered employed by Epstein‐Barr virus, herpes simplex viruses, and human and murine cytomegaloviruses are described in this review.