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Molecular basis of immune evasion strategies by adenoviruses
Author(s) -
HAYDER HIKMAT,
MÜLLBACHER ARNO
Publication year - 1996
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1996.83
Subject(s) - immune system , biology , evasion (ethics) , virology , virus , host (biology) , innate immune system , immunology , acquired immune system , disease , genetics , medicine , pathology
Summary. Human adenoviruses have provided valuable insights into virus‐host interactions at the clinical and experimental levels. In addition to the medical importance of adenoviruses in acute infections and the ability of the virus to persist in the host, adenovirus‐based recombinants are being developed as potential vaccine vectors. It is now clear that adenoviruses employ various strategies to modulate the innate and the adaptive host immune defences. Adenovirus genome‐coded products that interact with the immune response of the host have been identified, and to a large extent the molecular mechanisms of their functions have been revealed. Such knowledge will no doubt influence our approach to the areas of viral pathogenesis, vaccine development and immune modulation for disease management.