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The effect of BCG, zymosan and Coxiella burnetti extract on Eimeria infections
Author(s) -
SMITH NC,
OVINGTON KS
Publication year - 1996
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1996.61
Subject(s) - eimeria , zymosan , biology , coccidiosis , eimeria acervulina , spleen , immunity , in vivo , immunology , microbiology and biotechnology , immune system , in vitro , medicine , veterinary medicine , biochemistry
Summary Infection of animals with species of Eimeria induces a hyper‐reactivity to endotoxin as manifest by a greatly increased capacity of infected animals to produce TNF in response to LPS in vivo compared with uninfected animals. This finding indicates priming for hyperactivation of macrophages by Eimeria infection and raises the possibility that non‐specific triggering of macrophages by agents such as Bacille Calmette‐Guerin (BCG), zymosan or Coxiella burnetti extract may be a simple means of control for coccidiosis. However, all of these agents enhanced oocyst excretion in mice, rats or chickens infected with Eimeria vermiformis. Eimeria nieschulzi or Eimeria tenella , respectively, without affecting the patent period.