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The relevance of murine animal models to study the development of allergic bronchial asthma
Author(s) -
HERZ UDO,
LUMPP USCHI,
PALMA JOAO CASIMIRO,
ENSSLE KARLHEINZ,
TAKATSU KIYOSHI,
SCHNOY NORBERT,
DASER ANGELIKA,
KÖTTGEN ECKART,
WAHN ULRICH,
RENZ HARALD
Publication year - 1996
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1996.30
Subject(s) - immunology , eosinophil , asthma , sensitization , allergic inflammation , allergy , immunoglobulin e , effector , immune system , inflammation , medicine , biology , antibody
Summary Bronchial asthma (BA) develops on the basis of a genetic predisposition and involves a characteristic sequence of changes in immune functions. In the immunopathogenesis, several phases can be distinguished: the initial stage is defined as the development of allergic sensitization. This step is dependent on: (i) T cell activation; (ii) IL‐4 production; (iii) IgE synthesis; and (iv) mediator release by effector cells. The second phase of allergic inflammation as a consequence of the T cell dependent sensitization is characterized by IL‐5 production and eosinophil activation and recruitment. Airway mucosa remodelling is the consequence of chronic inflammatory processes and represents the final stage of BA. In this article animal models will be discussed with regard to their relevance for these different phases in development of chronic allergic BA.