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Populations of thymocytes and peripheral blood leucocytes in leukaemia‐bearing mice treated with G‐CSF
Author(s) -
KAWIAK J,
HOSER G,
MIKS B,
POJDA Z,
SOBICZEWSKA A,
MACHAJ E,
WREMBEL A
Publication year - 1996
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1996.22
Subject(s) - thymocyte , homing (biology) , peripheral blood , immunology , bone marrow , biology , t lymphocyte , t cell , antigen , immune system , ecology
Summary The influence of granulocyle‐colony stimulating factor (G‐CSF) on thymocyte subsets and peripheral blood leucocytes in leukaemia L1210‐bearing mice was evaluated. Leukaemia‐bearing mice have a markedly reduced L3T4 + Lyt2 + thymocyte subpopulation. We observed ‘correction’ of relative values of thymocyte subpopulations induced by treatment of mice with a G‐CSF preparation. The suggestion is presented that this could result from liberation of lymphocyte T precursor cells from the bone marrow and increased homing of them into the thymus. The direct or indirect influence of G‐CSF on the L3T4 + Lyt2 + subpopulation of thymocytes is discussed.