Populations of thymocytes and peripheral blood leucocytes in leukaemia‐bearing mice treated with G‐CSF | Zendy

KAWIAK J | Zendy; HOSER G | Zendy; MIKS B | Zendy; POJDA Z | Zendy; SOBICZEWSKA A | Zendy; MACHAJ E | Zendy; WREMBEL A | Zendy

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Populations of thymocytes and peripheral blood leucocytes in leukaemia‐bearing mice treated with G‐CSF

Author(s) -

KAWIAK J,

HOSER G,

MIKS B,

POJDA Z,

SOBICZEWSKA A,

MACHAJ E,

WREMBEL A

Publication year - 1996

Publication title -

immunology and cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.999

H-Index - 104

eISSN - 1440-1711

pISSN - 0818-9641

DOI - 10.1038/icb.1996.22

Subject(s) - thymocyte , homing (biology) , peripheral blood , immunology , bone marrow , biology , t lymphocyte , t cell , antigen , immune system , ecology

Summary The influence of granulocyle‐colony stimulating factor (G‐CSF) on thymocyte subsets and peripheral blood leucocytes in leukaemia L1210‐bearing mice was evaluated. Leukaemia‐bearing mice have a markedly reduced L3T4 + Lyt2 + thymocyte subpopulation. We observed ‘correction’ of relative values of thymocyte subpopulations induced by treatment of mice with a G‐CSF preparation. The suggestion is presented that this could result from liberation of lymphocyte T precursor cells from the bone marrow and increased homing of them into the thymus. The direct or indirect influence of G‐CSF on the L3T4 + Lyt2 + subpopulation of thymocytes is discussed.

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