Interleukin‐4 inhibits the expression of tumour necrosis factors α and β, interleukins‐1 β and ‐6 and interferon‐γ
Author(s) -
LEE JEFFREY D.,
RHOADES KRISTINA,
ECONOMOU JAMES S.
Publication year - 1995
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1995.9
Subject(s) - cytokine , tumor necrosis factor alpha , interleukin , immune system , interferon gamma , immunology , inflammation , chemistry , biology
Summary T cell‐derived IL‐4 inhibits the expression of several inflammatory cytokine genes. In this study, IL‐4 downregulated TNF‐α and ‐β. IL‐1 β IL‐6 and IFN‐γ steady‐state mRNA and protein production by blood leucocytes. In a detailed kinetic analysis, cytokine mRNA levels were significantly decreased in the presence of IL‐4, suggesting an early and prolonged down regulatory effect. These findings support the general thesis that IL‐4 is an important regulator of the inflammatory immune response.