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Hierarchy of T cell antigen receptor assembly
Author(s) -
MANOLIOS NICHOLAS
Publication year - 1995
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1995.85
Subject(s) - t cell receptor , hierarchy , protein subunit , microbiology and biotechnology , receptor , structural similarity , biology , antigen , signal transduction , computational biology , chemistry , t cell , genetics , biochemistry , gene , immune system , economics , market economy
Summary The formation of partial complexes in an African green monkey kidney cell line (COS cells) has been used to examine assembly of newly synthesized T cell antigen receptor (TCR) chains. The identification of assembly interactions between multiple subunits and the formation of higher order subcomplexes has led to the development of a model for the hierarchy of subunit assembly leading to a complete TCR. These assembly interactions suggest likely nearest neighbour relationships in the assembling structure and probably reflect the quarternary structure ofthe TCR complex. This may be important when examining the association of other molecules with TCR proteins or when trying to discern structural components involved with signal transduction.