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The ecology and pathology of Epstein‐Barr virus
Author(s) -
SCHMIDT CHRISTOPHER W,
MISKO IHOR S
Publication year - 1995
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1995.79
Subject(s) - biology , latency (audio) , virus , epstein–barr virus , virology , replication (statistics) , immunology , computer science , telecommunications
Summary Epstein‐Barr virus achieves its ubiquitous and uniform epidemiological distribution by a dual strategy of latency to guarantee lifelong persistence and intermittent replication to guarantee transmission. These two functions appear to dictate residence in different cell types: latency in B lymphocytes and replication in epithelial cells. Both of these cell compartments are potential sites for FBV‐associated malignancies.