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Acute on chronic bronchitis: A model of mucosal immunology
Author(s) -
CLANCY ROBERT,
PANG GERALD,
DUNKLEY MARGARET,
TAYLOR DIANA,
CRIPPS ALLAN
Publication year - 1995
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1995.64
Subject(s) - immunology , chronic bronchitis , bronchitis , pathogenesis , mucosal immunology , inflammation , medicine , immunization , immunity , immune system
Summary Acute bronchitis has been studied as a model of disturbed mucosal immunoregulation. A new hypothesis relating to the pathogenesis of acute bronchitis has been developed, based on altered host response as the prime mover. Infection‐prone subjects had low levels of lysozyme. Effective oral immunization, especially if early, reduced levels of bacterial colonization. Future attention focuses on intra bronchial inflammation and its link to the host‐parasite relationship.