Premium
Increased level of activated γδ lymphocytes correlates with disease severity in HIV infection
Author(s) -
NORAZMI MOHDNOR,
ARIFIN HARUN,
JAMARUDDIN MAT ASAN
Publication year - 1995
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1995.40
Subject(s) - cd38 , flow cytometry , immunology , lymphocyte , il 2 receptor , hla dr , medicine , t lymphocyte , human immunodeficiency virus (hiv) , receptor , t cell , biology , immune system , antigen , genetics , stem cell , cd34
Summary The lymphocyte subset expressing the γδ T cell receptor is increased in several infectious diseases including HIV infection. In this study the expression on γδ lymphoctyes of the T cell activation markers CD25, HLA‐DR and CD38, as well as the two isoforms of CD45, namely CD45RA and CD45RO, was determined in the peripheral blood of 56 HIV‐infected intravenous drug users and 34 HIV‐seronegative blood donors by two‐colour flow cytometry. The percentage of γδ lymphocytes expressing HLA‐DR and CD38 was higher than those in HIV‐seronegative controls ( P < 0.001 and P < 0.0001, respectively). Furthermore the HLA‐DR + γδ + lymphocytes correlated inversely with CD4 + T lymphocyte absolute count ( P < 0.02 for both). The levels of γδ lymphocytes expressing CD25, CD45RA and CD45RO were similar to those in HIV‐seronegative controls. Activated γδ lymphocytes may play a role in the HIV disease process and could provide a useful marker for disease progression.