Premium
Putative functional domain within ORF2 on the Mycobacterium insertion sequences IS 900 and IS 902
Author(s) -
DORAN T. J.,
DAVIES J. K.,
RADFORD A. J.,
HODGSON A. L. M.
Publication year - 1994
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1994.63
Subject(s) - virulence , transposase , biology , homology (biology) , insertion sequence , gene , paratuberculosis , open reading frame , genetics , plasmid , encode , dna , microbiology and biotechnology , transposable element , mycobacterium , peptide sequence , bacteria , genome
Summary Repeated DNA sequences have been identified in a range of mycobacterial species and have been implicated in the increased virulence of some of these species, namely, Mycobacierium paratuberculosis and M. avium subsp. silvaticum. Here we present a case to suggest that the insertion sequences IS 900 and IS 902 encode a protein from a putative gene positioned on the complementary strand to their transposase genes. Based on amino acid homology analyses, this open reading frame (ORF2) could encode a transport protein. The ORF2 protein thus IS 900 and IS 902 , may have a role in the increased pathogenicity of M. paratuberculosis and M. avium subsp. silvaticum from an M. avium background.