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Characterization of a novel leucocyte activation antigen recognized by the antibody CMRF‐37
Author(s) -
DAISH A.,
HOCK B. D.,
HART D. N. J.
Publication year - 1994
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1994.3
Subject(s) - antigen , monoclonal antibody , kinetics , antibody , microbiology and biotechnology , stimulation , chemistry , immunohistochemistry , biology , immunology , neuroscience , physics , quantum mechanics
Summary We describe a novel activation antigen recognized by the monoclonal antibody CMRF‐37, which is absent or only weakly expressed on resting cells but is rapidly induced on T cells, B cells and monocytes following stimulation. Its kinetics of expression (12–24 h after the addition of the inductive signal) indicate that it is an early activation antigen. The cellular distribution and expression kinetics of the CMRF‐37 antigen differ from other known activation antigens and as such should be a useful marker of human leucocyte activation.