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The maintenance of self‐tolerance
Author(s) -
LAFFERTY KEVIN J.,
GILL RONALD G.
Publication year - 1993
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1993.23
Subject(s) - self tolerance , medicine , disease , autoimmunity
Summary Two signal models for lymphocyte activation build on the Talmage/Burnet concept that receptor diversity is generated within the immune system by a random process, and that individual lymphocytes carry a single receptor on their surface that determines their specificity. Such models cannot use a concept of signal one anergy (or deletion) to explain the maintenance of self‐tolerance in terms of the Bretscher/Cohn theory if they abandon the concept of associative recognition.