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In vivo inhibition of the rat primary antibody response to antigenic stimulation by somatostatin
Author(s) -
EGLEZOS ANTHONY,
ANDREWS PAUL V.,
HELME ROBERT D.
Publication year - 1993
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1993.13
Subject(s) - antibody response , in vivo , somatostatin , stimulation , antigen , antibody , chemistry , biology , immunology , endocrinology , genetics
Summary Somatostatin inhibits in vitro lymphocyte proliferative responses from a variety of species including human, mouse and rat. The immunoinhibitory effects of somatostatin are thought to involve binding to specific cell surface somatostatin receptors on immunocompetent cells. This report describes an in vivo immuno inhibitory effect of somatostatin on the rat pophteal lymph node lymphocyte primary antibody response to sheep red blood cell (SRBC) stimulation. Infusion of somatostatin immediately following SRBC injection into the hind feet of rats had a dose‐related inhibitory effect. At the highest concentration used, 10 μmol/L, the level of inhibition was similar to that previously described following neonatal capsaicin treatment of rats. This suggests that neonatal capsaicin treatment may lead to decreased primary antibody responses to SRBC by a selective effect on tachykinin containing nerves and a lesser effect on somatostatin containing nerves. The immuno inhibitory effect of somatostatin was reversed by co infusion of neurokinin A but not substance P, both of which have been shown to stimulate this response. This suggests the possibility that multiple tachykinin receptors are involved in the modulation of the SRBC primary antibody response in vivo These results present evidence for an in vivo immunomodulatory role of somatostatin.