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Intradermal and percutaneous transudation of IgG 1 and transferrin in sheep
Author(s) -
COLDITZ I. G.,
ALTMANN K. G.,
WATSON D. L.
Publication year - 1992
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1992.41
Subject(s) - transferrin , vascular permeability , transudate , chemistry , immunology , medicine , pathology , pleural fluid , pleural effusion
Summary The leakage of [ 125 I]‐IgG 1 into skin sites following injection of mediators of enhanced vascular permeability and during induction of transudates on the skin surface under negative pressure was examined to determine whether IgG is selectively transported into cutaneous transudates. 111 In‐transferrin was employed as a marker of plasma leakage unaided by selective transport. The leakage of IgG 1 into interstitial spaces of untreated skin, into inflammatory transudates and into transudate fluid drawn to the skin surface under vacuum occurred at a lower rate than did leakage of transferrin. No evidence was found in favour of a selective transport mechanism to aid transport of IgG 1 into extravascular skin compartments.