Premium
T cell receptor α‐chain polymorphic allele frequencies in Caucasians and Polynesians
Author(s) -
GEURSEN A.,
COUPER A.,
ABBOTT W. G. H.,
CAIRNS L. M.
Publication year - 1992
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1992.32
Subject(s) - allele , polynesians , biology , genetics , receptor , allele frequency , pacific islanders , southern blot , microbiology and biotechnology , gene , restriction fragment length polymorphism , polymerase chain reaction , ethnic group , demography , population , sociology , anthropology
Summary Restriction length polymorphisms in the variable and constant regions of the T cell receptor α‐chain were examined in 42 Caucasians, 29 Maoris and 27 Pacific Islanders. Southern blots of Tag I digested DNA were hybridized with the T cell receptor α‐chain probe pY14. Our results confirm that a 1.4 kb T cell receptor α chain‐Tag 1 band is allelic to a 0.5 kb band. A significant difference in the frequency of the 1.4 and 0.5 kb alleles of the variable region of the α‐chain was detected in Caucasians when compared with Maoris or Pacific Islanders (P < 0.0001). No differences in the frequency of the 2.0 and 7.0 kb alleles of the constant region gene were detected between any of the racial groups. These data may be relevant to ethnic differences in susceptibility to immune disorders.