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The induction of plasma leakage in skin by histamine, bradykinin, activated complement, platelet‐activating factor and serotonin
Author(s) -
COLDITZ I. G.
Publication year - 1991
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1991.31
Subject(s) - bradykinin , histamine , serotonin , platelet , chemistry , pharmacology , endocrinology , medicine , receptor
Summary Vascular leakage of [ 125 I]‐human serum albumin into the skin of sheep was measured in response to intradermal injection of histamine, bradykinin, zymosan‐activated plasma (ZAP), platelet‐activating factor (PAF) and serotonin. Potency of the mediators was PAF > ZAP > bradykinin ∼ histamine > serotonin. Maximal leakage occurred in the first 10 min following injection of bradykinin, histamine and PAF, and for histamine and bradykinin had effectively ceased by 40 min. In contrast, ZAP and serotonin induced relatively constant plasma leakage over the first 40 min following their intradermal injection. Prostaglandins E 1 and E 2 enhanced plasma leakage induced by histamine and bradykinin thus confirming the applicability of the two‐mediator hypothesis of vascular leakage to permeability responses in skin of sheep.