Premium
Murine candidiasis: Sex differences in the severity of tissue lesions are not associated with levels of serum C3 and C5
Author(s) -
ASHMAN R. B.,
KAY P. H.,
LYNCH D. M.,
PAPADIMITRIOU J. M.
Publication year - 1991
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1991.2
Subject(s) - candida albicans , biology , serum concentration , immunology , complement (music) , corpus albicans , physiology , microbiology and biotechnology , endocrinology , genetics , gene , complementation , phenotype
Summary Mice deficient in the fifth component of complement are known to be extremely susceptible to lethal challenge with Candida albicans. However, male mice, that have significantly higher concentrations of serum C5 than females, were markedly more susceptible to infection. This difference was observed in both susceptible (CBA/H) and resistant (BALB/c) mice. Levels of serum C3 likewise showed no correlation with susceptibility.