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Enhancement of u.v.‐induced skin carcinogenesis in the hairless mouse by inoculation with cell‐free extracts of skin tumours
Author(s) -
Reeve VE,
Greenoak GE,
Canfield PJ,
BoehmWilcox C,
Tilbrook PA,
Kulski JK,
Gallagher CH
Publication year - 1989
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1989.59
Subject(s) - hairless , carcinogenesis , carcinogen , ultraviolet light , biology , cell , dna , skin cancer , microbiology and biotechnology , pathology , cancer research , chemistry , cancer , medicine , biochemistry , genetics , photochemistry
Summary The presence of papillomaviral‐like DNA has been described in ultraviolet light‐induced tumours in the skin of the hairless mouse (14). Here we describe the effects of the inoculation of cell‐free extracts of ultraviolet light‐induced tumours into the scarified skin of normal hairless mice, prior to exposure of the mice to a cumulative carcinogenic dose of ultraviolet light. Extracts from papillomas or squamous cell carcinomas enhanced the susceptibility of the inoculated mice to ultraviolet light‐induced tumorigenesis, if the extracts contained papillomaviral DNA sequences detected by cross‐hybridization with Mastomys natalensis papillomaviral DNA. The recipient mice developed a greater tumour incidence, tumour yield, tumour diameter and degree of malignancy.