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HLA (Class I) antigens on platelets are involved in platelet function
Author(s) -
Cosgrove Leah J,
Vaughan Hilary A,
Tjandra Joe J,
Thurlow Peter J,
McKenzie Ian FC
Publication year - 1988
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1988.9
Subject(s) - platelet , monoclonal antibody , human leukocyte antigen , antigen , immunology , epitope , antibody , thrombin , major histocompatibility complex , chemistry , biology , microbiology and biotechnology
Summary HLA (Class I) antigens are ubiquitous in their cellular distribution and, while their function in major histocompatability complex (MHC)‐restricted phenomena are clear, their function on other cells, such as platelets, is not so obvious. We now report that several anti‐HLA monoclonal antibodies (including an anti‐β 2 microglobulin antibody) selectively affect platelet function in that three different anti‐HLA monoclonal antibodies caused not only the aggregation of human platelets, but also caused the release of 14 C‐serotonin. In addition, the anti‐HLA antibodies could selectively block the binding of several platelet agonists such as collagen, adrenalin, ADP, but not the binding of others such as thrombin and arachidonic acid. In blocking studies there also appeared to be an association between platelet glycoprotein IIb‐IIIa and HLA Class I antigens. We propose that both heavy and light chains of Class I HLA antigens on platelets may be involved in platelet aggregation and release and suggest an additional role for HLA antigens on platelets.