Premium
Murine candidiasis: Strain dependence of host responses after immunization
Author(s) -
Ashman RB,
Papadimitriou JM
Publication year - 1988
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1988.29
Subject(s) - host (biology) , immunization , strain (injury) , biology , virology , microbiology and biotechnology , immunology , genetics , immune system , anatomy
Summary After recovery from acute infection with live Candida albicans , both CBA/H and BALB/c mice show increased resistance to colonization by the organism. However, the ‘susceptible’ CBA/H mice develop much stronger protective responses than do ‘resistant’ BALB/c mice. This is manifested particularly as a substantial amelioration of the severity of the lesions in the brain, and a very marked reduction in the number of fungal units therein. Analysis of granulocyte function in normal and immune mice of the two strains tended to exclude this as a basis for the different patterns of susceptibility and resistance.