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Specific IgA antibody response in Ross River virus infection
Author(s) -
Carter IWJ,
Fraser JRE,
Cloonan MJ
Publication year - 1987
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.1987.60
Subject(s) - antibody response , virology , ross river virus , antibody , virus , biology , immunology , alphavirus
Summary Sera were collected over a period of several years from the onset of initial symptoms from 77 patients with Ross River virus infection. When tested for virus‐specific IgA antibodies, using an enzyme‐linked immunosorbent assay (ELISA) based on antibody class capture, 245 out of 704 sera were antibody‐positive. Although Ross River virus IgA antibodies were present in the serum of all patients soon after onset of symptoms, the IgA response was relatively short‐lived in comparison with specific IgM antibodies. The results suggested that the detection of high levels of Ross River virus IgA antibodies was of potential value in differentiating between recent and past infection, especially in those patients with persisting IgM antibodies.