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IMMUNOSUPPRESSION IN MURINE MALARIA: ROLE OF ACTIVATED MACROPHAGES
Author(s) -
Mahajan RC,
Ganguly NK,
Thadani M,
Prasad RN
Publication year - 1986
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1986.7
Subject(s) - plasmodium berghei , immunosuppression , spleen , immunology , macrophage , biology , malaria , immune system , virology , in vitro , biochemistry
Summary The role of macrophages in immunosuppression which develops during Plasmodium berghei infection in mice has been studied. The transfer of activated macrophages (or their extracts) from the infected mice with low parasitaemia (< 10%) to uninfected mice enhanced their humoral response to sheep red blood cells (SRBC) as indicated by the number of splenic IgM and IgG plaque–forming cells (PFC). In contrast, when macrophages obtained during higher parasitaemia (16%) were used, significant inhibition was observed. These findings indicate that during Plasmodium berghei infection in mice macrophages may play a dual role.