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CHANGES IN VENTILATION, BREATHING PATTERN AND ACID‐BASE BALANCE OF CONSCIOUS RABBITS FOLLOWING INTRAVENOUS ALMITRINE
Author(s) -
Maskrey M
Publication year - 1986
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1986.41
Subject(s) - ventilation (architecture) , acid–base homeostasis , anesthesia , tidal volume , acidosis , respiration , respiratory minute volume , context (archaeology) , respiratory acidosis , respiratory system , arterial blood , medicine , control of respiration , metabolic acidosis , alkalosis , biology , anatomy , mechanical engineering , paleontology , engineering
Summary Five conscious rabbits each received a single injection of almitrine bismesylate via a marginal ear vein. Measurements were made of ventilation and breathing pattern using a barometric method, and blood gases, pH and lactate concentration ([Lac]) were measured from arterial blood samples throughout the hour following the injection. Almitrine caused an immediate increase in ventilation through an increase in tidal volume (V T ), frequency (f) showing a small decline. After 15 min f increased to above control level and V T declined. Slower, deeper breathing was reinstated by 40 min post‐injection. Large changes in blood gases occurred in the first 15 min, withP O 2raised by 30 Torr andPCO 2lowered by 20 Torr. These recovered to be within 10 and 7·5 Torr of control at the end of 1 h. [Lac] increased steeply at first, then declined towards control levels. The acid‐base situation was mixed, comprising a respiratory alkalosis, resulting from CO 2 washout, and a metabolic acidosis from high [Lac]. These results are discussed in the context of assessing the primary and secondary effects of almitrine and recognition of the possibility that the drug may act at more than one site to alter respiration.