PROTECTIVE ANTIGENS IN FRACTIONS OF ADULT  NEMATOSPIROIDES DUBIUS | Zendy

Monroy FG | Zendy; Dobson Colin | Zendy

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PROTECTIVE ANTIGENS IN FRACTIONS OF ADULT NEMATOSPIROIDES DUBIUS

Author(s) -

Monroy FG,

Dobson Colin

Publication year - 1986

Publication title -

australian journal of experimental biology and medical science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.999

H-Index - 104

eISSN - 1440-1711

pISSN - 0004-945X

DOI - 10.1038/icb.1986.35

Subject(s) - antigen , immunology , biology

Summary Adult Nematospiroides dubius crude soluble homogenate consistently produced five fractions (Fl‐5) after filtration through Sephadex G‐200 with molecular weights of >300,000, 240,000, 83,000, 31,000 and < 10,000. The high molecular weight Fl and F2 reacted strongly with serum from previously infected mice in ELISA. Protective immunity was associated with Fl N. dubius immunogens (molecular weight > 300,000). Immunization with smaller molecular weight fractions also reduced worm recoveries following challenge infections but to a lesser extent.

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