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PROTECTIVE ANTIGENS IN FRACTIONS OF ADULT NEMATOSPIROIDES DUBIUS
Author(s) -
Monroy FG,
Dobson Colin
Publication year - 1986
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1986.35
Subject(s) - antigen , immunology , biology
Summary Adult Nematospiroides dubius crude soluble homogenate consistently produced five fractions (Fl‐5) after filtration through Sephadex G‐200 with molecular weights of >300,000, 240,000, 83,000, 31,000 and < 10,000. The high molecular weight Fl and F2 reacted strongly with serum from previously infected mice in ELISA. Protective immunity was associated with Fl N. dubius immunogens (molecular weight > 300,000). Immunization with smaller molecular weight fractions also reduced worm recoveries following challenge infections but to a lesser extent.