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THE IMMUNOLOGICAL CONSEQUENCES OF ALLOGENEIC RAT EMBRYO TRANSFER
Author(s) -
McCullagh Peter
Publication year - 1985
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1985.67
Subject(s) - embryo , andrology , embryo transfer , immunology , biology , strain (injury) , transplantation , microbiology and biotechnology , medicine , anatomy
Summary Blastocysts of the PVG and DA rat strains were transferred to pseudopregnant females of the opposite strain. Those embryos of which the biological and surrogate mothers were allogeneic with respect to each other exhibited a significantly impaired rate of survival. Lymphocytes from PVG rats born following the transfer of blastocysts to DA surrogates invariably possessed anti‐(PVG × DA)F 1 hybrid graft‐versus‐host reactivity substantially in excess of that of cells from normal PVG rats.